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The medication contains both Irbesartan and Hydrochlorothiazide. Irbesartan helps relax blood vessels. Hydrochlorothiazide, or HCTZ helps rid your body of excess water and salt. Detailed dosage guidelines and administration information for Avalide (irbesartan and hydrochlorothiazide). Includes dose adjustments, warnings and precautions. AVALIDE® (irbesartan and hydrochlorothiazide) tablets are indicated for the treatment of hypertension. AVALIDE may be used in patients whose blood pressure is not adequately controlled on monotherapy. AVALIDE may also be used as initial therapy in patients who are likely to need multiple drugs to achieve their blood pressure goals. Avalide (irbésartan and hydrochlorothiazide) Indications Avalide is used to treat high blood pressure (hypertension). It helps lower blood pressure to reduce the risk of strokes, heart attacks, and kidney problems. Dosage and Administration Take Avalide exactly as prescribed by your doctor, usually once daily. 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