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It is available in multiple brand and generic versions. It is not covered by most Medicare and insurance plans, but manufacturer and pharmacy coupons can help offset the cost. Renova cream is the only tretinoin product that's FDA approved to treat wrinkles. It also comes as a branded generic (Refissa). The topical tretinoin products that are FDA approved to treat acne include: Retin-A cream and gel Retin-A Micro gel Atralin gel Avita cream and gel Altreno lotion Tretinoin cream and gel are available as generic … Refissa Generic Renova Drug Info Side Effects Dosage Medicare Scan to get these savings in the GoodRx app. Check your prescription Pricing is calculated based on your prescription details. Generic medications may be manufactured by different companies. This means some generics vary in size, color, and shape. But the active ingredients are always the same. Amazon Pharmacy uses different manufacturers to ensure medication supply and offer low prices for our customers. 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