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It is used to treat symptoms of seasonal and year round allergies such as: Xyzal (Levocetirizine) is an allergy medication that is available over the counter beginning Spring 2017. Xyzal was initially approved in 2007 by the FDA as a prescription only medication indicated for the treatment of seasonal and year round allergy symptoms. In this article, we will discuss everything you want to know about Xyzal OTC! What Is … With Xyzal Allergy 24 Hour, you don't have to worry about your allergy medicine wearing off before the next dose. It's clinically proven to start working in 60 minutes and continues to provide relief for a full 24 hours. In fact, Xyzal Allergy 24 Hour maintains its effectiveness from the first hour through the 24th hour. Ways to save on generic Xyzal Allergy These programs and tips can help make your prescription more affordable Fill a 90-Day Supply to Save You may be able to lower your total cost by filling a greater quantity at one time. 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