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Sulfamethoxazole-Trimethoprim or Bactrim Ds Savings, Coupons and Information. | SULFAMETHOXAZOLE; TRIMETHOPRIM (suhl fuh meth OK suh zohl; trye METH oh prim) treats infections caused by bacteria. It belongs to a group of medications called sulfonamide antibiotics. Discover if Bactrim is available over-the-counter and learn about its uses, side effects, and prescription alternatives for treating bacterial infections. How much does sulfamethoxazole-trimethoprim cost without insurance? People without insurance coverage can expect to pay the full cash price for a sulfamethoxazole-trimethoprim prescription. The average retail price for 20, 800-160 mg tablets of sulfamethoxazole-trimethoprim is about $24. How long that lasts will depend on the dosage prescribed. Amazon.com: bactrim ds PillPack, LLC by Amazon Pharmacy has been accredited by the National Association of Boards of Pharmacy® (NABP®) for Digital Pharmacy. 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