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General description of Actos Actos, also known by its generic name pioglitazone, is a medication used to treat type 2 diabetes mellitus. It belongs to a class of drugs called thiazolidinediones, which help control blood sugar levels by increasing the body's sensitivity to insulin. Actos is available in tablet form and is typically taken once daily with or without food. Over-the-counter medicines differ from prescription medicines but offer the same benefits. Find out how to use them properly. Transfer your prescription for PIOGLITAZONE 30 MG TAB on Amazon Pharmacy. FREE SHIPPING for Prime members. Actos (pioglitazone) is an oral diabetes medicine used to treat type 2 (non-insulin-dependent) diabetes. Includes Actos side effects, interactions and indications. When Actos is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. 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